Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5136434..5137059 | Replicon | chromosome |
Accession | NZ_CP098141 | ||
Organism | Klebsiella pneumoniae strain Z0117KP0025 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | NBY50_RS26515 | Protein ID | WP_002882817.1 |
Coordinates | 5136434..5136817 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | NBY50_RS26520 | Protein ID | WP_004150355.1 |
Coordinates | 5136817..5137059 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NBY50_RS26500 (5133800) | 5133800..5134702 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
NBY50_RS26505 (5134699) | 5134699..5135334 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
NBY50_RS26510 (5135331) | 5135331..5136260 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
NBY50_RS26515 (5136434) | 5136434..5136817 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
NBY50_RS26520 (5136817) | 5136817..5137059 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
NBY50_RS26525 (5137264) | 5137264..5138181 | + | 918 | WP_021466676.1 | alpha/beta hydrolase | - |
NBY50_RS26530 (5138195) | 5138195..5139136 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
NBY50_RS26535 (5139181) | 5139181..5139618 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
NBY50_RS26540 (5139615) | 5139615..5140475 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
NBY50_RS26545 (5140469) | 5140469..5141068 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T246691 WP_002882817.1 NZ_CP098141:c5136817-5136434 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |