Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4805332..4807013 | Replicon | chromosome |
| Accession | NZ_CP098141 | ||
| Organism | Klebsiella pneumoniae strain Z0117KP0025 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A6TH06 |
| Locus tag | NBY50_RS24965 | Protein ID | WP_015959269.1 |
| Coordinates | 4805332..4806207 (-) | Length | 292 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | NBY50_RS24970 | Protein ID | WP_004177809.1 |
| Coordinates | 4806255..4807013 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY50_RS24945 (4800638) | 4800638..4802158 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| NBY50_RS24950 (4802155) | 4802155..4803153 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| NBY50_RS24955 (4803184) | 4803184..4804125 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| NBY50_RS24960 (4804200) | 4804200..4805207 | + | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| NBY50_RS24965 (4805332) | 4805332..4806207 | - | 876 | WP_015959269.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NBY50_RS24970 (4806255) | 4806255..4807013 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| NBY50_RS24975 (4807099) | 4807099..4807827 | - | 729 | WP_032413197.1 | response regulator transcription factor | - |
| NBY50_RS24980 (4808100) | 4808100..4810247 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| NBY50_RS24985 (4810244) | 4810244..4810387 | - | 144 | WP_162897205.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 292 a.a. Molecular weight: 32990.17 Da Isoelectric Point: 5.4637
>T246690 WP_015959269.1 NZ_CP098141:c4806207-4805332 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 876 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT246690 WP_004177809.1 NZ_CP098141:c4807013-4806255 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|