24669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2600725..2601205 Replicon chromosome
Accession NC_013960
Organism Nitrosococcus halophilus Nc 4

Toxin (Protein)


Gene name pasB Uniprot ID D5BWF5
Locus tag NHAL_RS12305 Protein ID WP_013033472.1
Coordinates 2600933..2601205 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID D5BWF4
Locus tag NHAL_RS12300 Protein ID WP_013033471.1
Coordinates 2600725..2600949 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHAL_RS20520 2595774..2596066 - 293 Protein_2442 HigA family addiction module antidote protein -
NHAL_RS20525 2596066..2596149 - 84 WP_083761445.1 hypothetical protein -
NHAL_RS12270 2596168..2596473 - 306 WP_013033467.1 helix-turn-helix domain-containing protein -
NHAL_RS12275 2596889..2598282 - 1394 Protein_2445 IS4 family transposase -
NHAL_RS12280 2598459..2598707 - 249 WP_013033468.1 DUF2442 domain-containing protein -
NHAL_RS20530 2598715..2598885 - 171 WP_013033469.1 DUF4160 domain-containing protein -
NHAL_RS12285 2598882..2599082 - 201 WP_203434406.1 CopG family transcriptional regulator -
NHAL_RS12290 2599805..2600116 + 312 WP_049780642.1 IS110 family transposase -
NHAL_RS21625 2600217..2600417 - 201 WP_203434320.1 hypothetical protein -
NHAL_RS12300 2600725..2600949 + 225 WP_013033471.1 TraY domain-containing protein Antitoxin
NHAL_RS12305 2600933..2601205 + 273 WP_013033472.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHAL_RS12310 2601516..2602055 + 540 WP_049780643.1 IS110 family transposase -
NHAL_RS21210 2602132..2602287 + 156 WP_157862562.1 hypothetical protein -
NHAL_RS19865 2602381..2603073 - 693 WP_049780645.1 hypothetical protein -
NHAL_RS12320 2603191..2603976 - 786 WP_013033475.1 hypothetical protein -
NHAL_RS12325 2604035..2604361 - 327 WP_013033476.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin

Relaxosome protein TraY

(4-48)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10490.21 Da        Isoelectric Point: 10.1713

>T24669 WP_013033472.1 NC_013960:2600933-2601205 [Nitrosococcus halophilus Nc 4]
MAWQIELSGLAQKNLHGLDKQIAERILRFLNDRIAKLDDPRSIGDPLKGAKLGEFWKYRVGDYRIIADIQDSELLILVVR
IGNRREVYKR

Download         Length: 273 bp

>T24669 NC_013960:2600933-2601205 [Nitrosococcus halophilus Nc 4]
ATGGCCTGGCAGATTGAGTTGTCGGGACTGGCGCAAAAAAACCTGCACGGACTGGATAAACAGATAGCGGAGCGAATCCT
ACGCTTTTTGAATGATCGGATCGCGAAGCTGGACGACCCGCGCAGTATCGGTGATCCCCTCAAGGGCGCGAAGCTGGGCG
AGTTCTGGAAATATCGTGTCGGTGATTATCGTATTATCGCCGATATTCAGGATAGCGAATTGCTGATTCTGGTGGTGCGG
ATTGGCAATCGCCGGGAGGTTTACAAGCGGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8467.70 Da        Isoelectric Point: 4.2821

>AT24669 WP_013033471.1 NC_013960:2600725-2600949 [Nitrosococcus halophilus Nc 4]
MLAIRLPKEIEERLEALAAATGRTKTFYARQAILEYIDDLEDVYLAERELEEVRAGRSIPVPLEDVMKQYGLAD

Download         Length: 225 bp

>AT24669 NC_013960:2600725-2600949 [Nitrosococcus halophilus Nc 4]
ATGTTGGCTATCCGACTCCCCAAGGAGATAGAGGAACGTCTGGAGGCGCTGGCCGCTGCTACCGGGCGCACCAAAACCTT
TTACGCCCGCCAAGCCATTCTGGAGTACATTGATGATCTGGAAGACGTGTACTTGGCCGAGCGTGAGCTAGAAGAAGTTC
GTGCGGGTCGCAGCATCCCCGTGCCTCTGGAAGACGTCATGAAGCAATATGGCCTGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D5BWF5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7C2V1

References