Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4644145..4644661 Replicon chromosome
Accession NZ_CP098141
Organism Klebsiella pneumoniae strain Z0117KP0025

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NBY50_RS24140 Protein ID WP_009486548.1
Coordinates 4644145..4644429 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NBY50_RS24145 Protein ID WP_002886901.1
Coordinates 4644419..4644661 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY50_RS24115 (4639562) 4639562..4639825 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NBY50_RS24120 (4639955) 4639955..4640128 + 174 WP_032433782.1 hypothetical protein -
NBY50_RS24125 (4640131) 4640131..4640874 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY50_RS24130 (4641231) 4641231..4643369 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY50_RS24135 (4643677) 4643677..4644141 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY50_RS24140 (4644145) 4644145..4644429 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY50_RS24145 (4644419) 4644419..4644661 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY50_RS24150 (4644739) 4644739..4646649 - 1911 WP_009486549.1 PRD domain-containing protein -
NBY50_RS24155 (4646672) 4646672..4647826 - 1155 WP_002886900.1 lactonase family protein -
NBY50_RS24160 (4647893) 4647893..4648633 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T246689 WP_009486548.1 NZ_CP098141:c4644429-4644145 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT246689 WP_002886901.1 NZ_CP098141:c4644661-4644419 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References