Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3891017..3891636 Replicon chromosome
Accession NZ_CP098141
Organism Klebsiella pneumoniae strain Z0117KP0025

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NBY50_RS20565 Protein ID WP_002892050.1
Coordinates 3891418..3891636 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag NBY50_RS20560 Protein ID WP_002892066.1
Coordinates 3891017..3891391 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY50_RS20550 (3886169) 3886169..3887362 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY50_RS20555 (3887385) 3887385..3890531 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
NBY50_RS20560 (3891017) 3891017..3891391 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
NBY50_RS20565 (3891418) 3891418..3891636 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NBY50_RS20570 (3891799) 3891799..3892365 + 567 WP_002892030.1 maltose O-acetyltransferase -
NBY50_RS20575 (3892337) 3892337..3892477 - 141 WP_004147370.1 hypothetical protein -
NBY50_RS20580 (3892498) 3892498..3892968 + 471 WP_020802585.1 YlaC family protein -
NBY50_RS20585 (3892943) 3892943..3894394 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
NBY50_RS20590 (3894495) 3894495..3895193 + 699 WP_023287311.1 GNAT family protein -
NBY50_RS20595 (3895190) 3895190..3895330 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
NBY50_RS20600 (3895330) 3895330..3895593 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246687 WP_002892050.1 NZ_CP098141:3891418-3891636 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT246687 WP_002892066.1 NZ_CP098141:3891017-3891391 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References