Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2624919..2626507 Replicon chromosome
Accession NZ_CP098141
Organism Klebsiella pneumoniae strain Z0117KP0025

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NBY50_RS14495 Protein ID WP_002904792.1
Coordinates 2624919..2626241 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NBY50_RS14500 Protein ID WP_002904790.1
Coordinates 2626241..2626507 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY50_RS14480 (2619975) 2619975..2622476 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
NBY50_RS14485 (2622464) 2622464..2623468 + 1005 WP_032433097.1 fimbrial protein -
NBY50_RS14490 (2623610) 2623610..2624902 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY50_RS14495 (2624919) 2624919..2626241 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY50_RS14500 (2626241) 2626241..2626507 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY50_RS14505 (2626893) 2626893..2627219 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NBY50_RS14510 (2627216) 2627216..2627716 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY50_RS14515 (2627694) 2627694..2629073 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
NBY50_RS14520 (2629419) 2629419..2630573 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY50_RS14525 (2630554) 2630554..2631477 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T246686 WP_002904792.1 NZ_CP098141:c2626241-2624919 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT246686 WP_002904790.1 NZ_CP098141:c2626507-2626241 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References