Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1433514..1434250 Replicon chromosome
Accession NZ_CP098141
Organism Klebsiella pneumoniae strain Z0117KP0025

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag NBY50_RS08525 Protein ID WP_032433360.1
Coordinates 1433768..1434250 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NBY50_RS08520 Protein ID WP_003026799.1
Coordinates 1433514..1433780 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY50_RS08495 (1429160) 1429160..1430299 + 1140 WP_032433368.1 mannitol dehydrogenase -
NBY50_RS08500 (1430328) 1430328..1430990 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
NBY50_RS08505 (1430971) 1430971..1431978 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
NBY50_RS08510 (1431996) 1431996..1432628 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
NBY50_RS08515 (1432638) 1432638..1433201 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
NBY50_RS08520 (1433514) 1433514..1433780 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NBY50_RS08525 (1433768) 1433768..1434250 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
NBY50_RS08530 (1434611) 1434611..1435210 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
NBY50_RS08535 (1435423) 1435423..1436367 - 945 WP_077254249.1 fimbrial protein -
NBY50_RS08540 (1436379) 1436379..1436957 - 579 WP_032432061.1 type 1 fimbrial protein -
NBY50_RS08545 (1436961) 1436961..1437701 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1401459..1445193 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T246681 WP_032433360.1 NZ_CP098141:1433768-1434250 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT246681 WP_003026799.1 NZ_CP098141:1433514-1433780 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References