Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 137437..138188 Replicon plasmid pZ0117KP0025-1
Accession NZ_CP098140
Organism Klebsiella pneumoniae strain Z0117KP0025

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag NBY50_RS00730 Protein ID WP_014386536.1
Coordinates 137437..137919 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NBY50_RS00735 Protein ID WP_004902250.1
Coordinates 137910..138188 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY50_RS00710 (NBY50_00710) 133836..134483 - 648 WP_014386537.1 EcsC family protein -
NBY50_RS00715 (NBY50_00715) 134510..135265 - 756 WP_004902235.1 DUF2971 domain-containing protein -
NBY50_RS00720 (NBY50_00720) 135366..135758 - 393 WP_032442757.1 hypothetical protein -
NBY50_RS00725 (NBY50_00725) 135863..136402 - 540 WP_004902239.1 hypothetical protein -
NBY50_RS00730 (NBY50_00730) 137437..137919 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
NBY50_RS00735 (NBY50_00735) 137910..138188 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NBY50_RS00740 (NBY50_00740) 138307..138519 - 213 WP_004902255.1 hypothetical protein -
NBY50_RS00745 (NBY50_00745) 138627..138968 - 342 WP_004902257.1 hypothetical protein -
NBY50_RS00750 (NBY50_00750) 139798..140256 - 459 WP_014386535.1 hypothetical protein -
NBY50_RS00755 (NBY50_00755) 140909..141364 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
NBY50_RS00760 (NBY50_00760) 141436..141801 + 366 WP_001294656.1 mercuric ion transporter MerT -
NBY50_RS00765 (NBY50_00765) 141817..142092 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
NBY50_RS00770 (NBY50_00770) 142120..142545 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / sul1 / blaDHA-1 / qnrB4 / qacE / ARR-3 / aac(6')-Ib-cr - 1..267989 267989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T246675 WP_014386536.1 NZ_CP098140:c137919-137437 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT246675 WP_004902250.1 NZ_CP098140:c138188-137910 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References