Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4705275..4706011 Replicon chromosome
Accession NZ_CP098136
Organism Klebsiella pneumoniae strain Z0117KP0027

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag NBY52_RS24470 Protein ID WP_032433360.1
Coordinates 4705529..4706011 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NBY52_RS24465 Protein ID WP_003026799.1
Coordinates 4705275..4705541 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY52_RS24440 (4700921) 4700921..4702060 + 1140 WP_032433368.1 mannitol dehydrogenase -
NBY52_RS24445 (4702089) 4702089..4702751 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
NBY52_RS24450 (4702732) 4702732..4703739 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
NBY52_RS24455 (4703757) 4703757..4704389 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
NBY52_RS24460 (4704399) 4704399..4704962 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
NBY52_RS24465 (4705275) 4705275..4705541 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NBY52_RS24470 (4705529) 4705529..4706011 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
NBY52_RS24475 (4706372) 4706372..4706971 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
NBY52_RS24480 (4707184) 4707184..4708128 - 945 WP_077254249.1 fimbrial protein -
NBY52_RS24485 (4708140) 4708140..4708718 - 579 WP_032432061.1 type 1 fimbrial protein -
NBY52_RS24490 (4708722) 4708722..4709462 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4673220..4716954 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T246669 WP_032433360.1 NZ_CP098136:4705529-4706011 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT246669 WP_003026799.1 NZ_CP098136:4705275-4705541 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References