Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4688584..4689227 Replicon chromosome
Accession NZ_CP098136
Organism Klebsiella pneumoniae strain Z0117KP0027

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag NBY52_RS24375 Protein ID WP_032433387.1
Coordinates 4688811..4689227 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NBY52_RS24370 Protein ID WP_001261276.1
Coordinates 4688584..4688814 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY52_RS24355 (4683606) 4683606..4684693 + 1088 Protein_4479 transcriptional repressor PifC -
NBY52_RS24360 (4684696) 4684696..4686936 + 2241 WP_045326788.1 P-loop NTPase fold protein -
NBY52_RS24365 (4687464) 4687464..4688279 - 816 WP_032433388.1 hypothetical protein -
NBY52_RS24370 (4688584) 4688584..4688814 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NBY52_RS24375 (4688811) 4688811..4689227 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY52_RS24380 (4689383) 4689383..4690363 + 981 WP_032433385.1 hypothetical protein -
NBY52_RS24385 (4690558) 4690558..4692129 - 1572 WP_032433383.1 AAA family ATPase -
NBY52_RS24390 (4692448) 4692448..4692696 + 249 WP_032433382.1 hypothetical protein -
NBY52_RS24395 (4692755) 4692755..4693273 + 519 WP_045326794.1 hypothetical protein -
NBY52_RS24400 (4693304) 4693304..4693795 + 492 WP_032433378.1 hypothetical protein -
NBY52_RS24405 (4693855) 4693855..4694058 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4673220..4716954 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T246668 WP_032433387.1 NZ_CP098136:4688811-4689227 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT246668 WP_001261276.1 NZ_CP098136:4688584-4688814 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References