Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4056932..4057589 Replicon chromosome
Accession NZ_CP098136
Organism Klebsiella pneumoniae strain Z0117KP0027

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY52_RS21300 Protein ID WP_002916310.1
Coordinates 4057179..4057589 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY52_RS21295 Protein ID WP_002916312.1
Coordinates 4056932..4057198 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY52_RS21270 (4052088) 4052088..4053521 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NBY52_RS21275 (4053640) 4053640..4054368 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY52_RS21280 (4054418) 4054418..4054729 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY52_RS21285 (4054893) 4054893..4055552 + 660 WP_002916317.1 hemolysin III family protein -
NBY52_RS21290 (4055703) 4055703..4056686 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NBY52_RS21295 (4056932) 4056932..4057198 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY52_RS21300 (4057179) 4057179..4057589 + 411 WP_002916310.1 protein YgfX Toxin
NBY52_RS21305 (4057596) 4057596..4058117 - 522 WP_004144730.1 flavodoxin FldB -
NBY52_RS21310 (4058218) 4058218..4059114 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY52_RS21315 (4059137) 4059137..4059850 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY52_RS21320 (4059856) 4059856..4061589 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246667 WP_002916310.1 NZ_CP098136:4057179-4057589 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246667 WP_002916312.1 NZ_CP098136:4056932-4057198 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References