Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3133633..3134258 Replicon chromosome
Accession NZ_CP098136
Organism Klebsiella pneumoniae strain Z0117KP0027

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NBY52_RS16690 Protein ID WP_002882817.1
Coordinates 3133633..3134016 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NBY52_RS16695 Protein ID WP_004150355.1
Coordinates 3134016..3134258 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY52_RS16675 (3130999) 3130999..3131901 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NBY52_RS16680 (3131898) 3131898..3132533 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NBY52_RS16685 (3132530) 3132530..3133459 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NBY52_RS16690 (3133633) 3133633..3134016 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY52_RS16695 (3134016) 3134016..3134258 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NBY52_RS16700 (3134463) 3134463..3135380 + 918 WP_021466676.1 alpha/beta hydrolase -
NBY52_RS16705 (3135394) 3135394..3136335 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NBY52_RS16710 (3136380) 3136380..3136817 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NBY52_RS16715 (3136814) 3136814..3137674 - 861 WP_004146232.1 virulence factor BrkB family protein -
NBY52_RS16720 (3137668) 3137668..3138267 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T246664 WP_002882817.1 NZ_CP098136:c3134016-3133633 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT246664 WP_004150355.1 NZ_CP098136:c3134258-3134016 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References