Detailed information of TA system TA246663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2802533..2804214
• Replicon: chromosome
• Accession: NZ_CP098136
• Organism: Klebsiella pneumoniae strain Z0117KP0027

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: NBY52_RS15140
• Protein ID: WP_015959269.1
• Coordinates: 2802533..2803408 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NBY52_RS15145
• Protein ID: WP_004177809.1
• Coordinates: 2803456..2804214 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY52_RS15120 (2797839)	2797839..2799359	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
NBY52_RS15125 (2799356)	2799356..2800354	+	999	WP_002885172.1	ribose ABC transporter permease	-
NBY52_RS15130 (2800385)	2800385..2801326	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
NBY52_RS15135 (2801401)	2801401..2802408	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
NBY52_RS15140 (2802533)	2802533..2803408	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NBY52_RS15145 (2803456)	2803456..2804214	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NBY52_RS15150 (2804300)	2804300..2805028	-	729	WP_032413197.1	response regulator transcription factor	-
NBY52_RS15155 (2805301)	2805301..2807448	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NBY52_RS15160 (2807445)	2807445..2807588	-	144	WP_162897205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T246663 WP_015959269.1 NZ_CP098136:c2803408-2802533 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT246663 WP_004177809.1 NZ_CP098136:c2804214-2803456 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05