Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2641346..2641862 Replicon chromosome
Accession NZ_CP098136
Organism Klebsiella pneumoniae strain Z0117KP0027

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NBY52_RS14315 Protein ID WP_009486548.1
Coordinates 2641346..2641630 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NBY52_RS14320 Protein ID WP_002886901.1
Coordinates 2641620..2641862 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY52_RS14290 (2636763) 2636763..2637026 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NBY52_RS14295 (2637156) 2637156..2637329 + 174 WP_032433782.1 hypothetical protein -
NBY52_RS14300 (2637332) 2637332..2638075 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY52_RS14305 (2638432) 2638432..2640570 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY52_RS14310 (2640878) 2640878..2641342 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY52_RS14315 (2641346) 2641346..2641630 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY52_RS14320 (2641620) 2641620..2641862 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY52_RS14325 (2641940) 2641940..2643850 - 1911 WP_009486549.1 PRD domain-containing protein -
NBY52_RS14330 (2643873) 2643873..2645027 - 1155 WP_002886900.1 lactonase family protein -
NBY52_RS14335 (2645094) 2645094..2645834 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T246662 WP_009486548.1 NZ_CP098136:c2641630-2641346 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT246662 WP_002886901.1 NZ_CP098136:c2641862-2641620 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References