Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 136024..136775 Replicon plasmid pZ0117KP0028-2
Accession NZ_CP098133
Organism Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag NBY54_RS27540 Protein ID WP_014386536.1
Coordinates 136024..136506 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NBY54_RS27545 Protein ID WP_004902250.1
Coordinates 136497..136775 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY54_RS27520 (NBY54_27495) 132423..133070 - 648 WP_014386537.1 EcsC family protein -
NBY54_RS27525 (NBY54_27500) 133097..133852 - 756 WP_004902235.1 DUF2971 domain-containing protein -
NBY54_RS27530 (NBY54_27505) 133953..134345 - 393 WP_032442757.1 hypothetical protein -
NBY54_RS27535 (NBY54_27510) 134450..134989 - 540 WP_004902239.1 hypothetical protein -
NBY54_RS27540 (NBY54_27515) 136024..136506 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
NBY54_RS27545 (NBY54_27520) 136497..136775 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NBY54_RS27550 (NBY54_27525) 136894..137106 - 213 WP_004902255.1 hypothetical protein -
NBY54_RS27555 (NBY54_27530) 137214..137555 - 342 WP_004902257.1 hypothetical protein -
NBY54_RS27560 (NBY54_27535) 138385..138843 - 459 WP_014386535.1 hypothetical protein -
NBY54_RS27565 (NBY54_27540) 139496..139951 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
NBY54_RS27570 (NBY54_27545) 140023..140388 + 366 WP_001294656.1 mercuric ion transporter MerT -
NBY54_RS27575 (NBY54_27550) 140404..140679 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
NBY54_RS27580 (NBY54_27555) 140707..141132 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aph(3')-Ia / aph(6)-Id / aph(3'')-Ib / sul2 / sul1 / blaDHA-1 / qnrB4 / qacE / ARR-3 / aac(6')-Ib-cr - 1..265597 265597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T246654 WP_014386536.1 NZ_CP098133:c136506-136024 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT246654 WP_004902250.1 NZ_CP098133:c136775-136497 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References