246652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4830772..4832360 Replicon chromosome
Accession NZ_CP098131
Organism Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NBY54_RS23610 Protein ID WP_002904792.1
Coordinates 4830772..4832094 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NBY54_RS23615 Protein ID WP_002904790.1
Coordinates 4832094..4832360 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY54_RS23595 (4825828) 4825828..4828329 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
NBY54_RS23600 (4828317) 4828317..4829321 + 1005 WP_032433097.1 fimbrial protein -
NBY54_RS23605 (4829463) 4829463..4830755 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY54_RS23610 (4830772) 4830772..4832094 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY54_RS23615 (4832094) 4832094..4832360 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY54_RS23620 (4832746) 4832746..4833072 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NBY54_RS23625 (4833069) 4833069..4833569 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY54_RS23630 (4833547) 4833547..4834926 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
NBY54_RS23635 (4835272) 4835272..4836426 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY54_RS23640 (4836407) 4836407..4837330 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T246652 WP_002904792.1 NZ_CP098131:c4832094-4830772 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT246652 WP_002904790.1 NZ_CP098131:c4832360-4832094 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References