Detailed information of TA system TA024665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 638930..639474
• Replicon: chromosome
• Accession: NC_013960
• Organism: Nitrosococcus halophilus Nc 4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D5BWT5
• Locus tag: NHAL_RS03115
• Protein ID: WP_013031710.1
• Coordinates: 639178..639474 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D5BWT4
• Locus tag: NHAL_RS03110
• Protein ID: WP_013031709.1
• Coordinates: 638930..639178 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NHAL_RS03075	634089..634703	+	615	WP_013031705.1	IS607 family transposase	-
NHAL_RS03080	634681..635835	+	1155	WP_013031706.1	transposase	-
NHAL_RS03085	636013..636324	+	312	WP_013031708.1	nucleotidyltransferase domain-containing protein	-
NHAL_RS03090	636321..636596	+	276	WP_203434354.1	hypothetical protein	-
NHAL_RS03095	636557..637780	-	1224	WP_013031487.1	IS256 family transposase	-
NHAL_RS03100	637894..638109	+	216	WP_203434355.1	hypothetical protein	-
NHAL_RS03105	638203..638757	-	555	Protein_616	transposase	-
NHAL_RS03110	638930..639178	+	249	WP_013031709.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
NHAL_RS03115	639178..639474	+	297	WP_013031710.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NHAL_RS03125	639992..640420	+	429	WP_013031712.1	DedA family protein	-
NHAL_RS03130	640861..641157	+	297	WP_013031713.1	PepSY domain-containing protein	-
NHAL_RS03135	641215..642564	-	1350	WP_013031714.1	MATE family efflux transporter	-
NHAL_RS03140	642703..643608	-	906	WP_013031715.1	OmpA family protein	-
NHAL_RS03145	643966..644349	-	384	WP_013031716.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (1-81)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11544.26 Da
• Isoelectric Point: 7.8670

>T24665 WP_013031710.1 NC_013960:639178-639474 [Nitrosococcus halophilus Nc 4]
MPGYRITPRAKADLKNIGRYTLKIWGKQQRDIYLKNLDQRFAWLAENPCLGKHRPDIEEGYYCFPQGSHLVFYLLREDGI
DIIGIPHQDMDILNYFNG

Nucleotide

• Length: 297 bp

>T24665 NC_013960:639178-639474 [Nitrosococcus halophilus Nc 4]
ATGCCCGGTTACAGGATTACACCACGGGCGAAAGCGGATTTGAAAAATATCGGGCGCTATACGCTCAAAATCTGGGGCAA
GCAACAACGCGATATTTATCTGAAAAATCTTGATCAACGCTTTGCCTGGCTGGCGGAAAATCCGTGTCTGGGAAAGCACC
GGCCTGATATAGAGGAAGGCTATTATTGCTTTCCCCAAGGCTCGCATCTGGTTTTTTATCTCCTACGTGAGGATGGCATT
GATATTATCGGTATTCCCCATCAGGATATGGATATTCTGAATTATTTTAACGGGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9223.23 Da
• Isoelectric Point: 4.5158

>AT24665 WP_013031709.1 NC_013960:638930-639178 [Nitrosococcus halophilus Nc 4]
MANTSLSLGEHWETFIKNEMASGRYGSASEVVRDALRLLEERRSKLDALRAHLGQGEAQAQRGEFVENYSIEAVITELDQ
EI

Nucleotide

• Length: 249 bp

>AT24665 NC_013960:638930-639178 [Nitrosococcus halophilus Nc 4]
ATGGCCAATACCAGTTTAAGCCTTGGAGAGCATTGGGAAACCTTCATTAAGAACGAAATGGCGAGCGGGCGCTACGGTTC
CGCCAGTGAAGTCGTACGCGATGCGCTGCGCTTGCTGGAAGAGAGGAGAAGCAAGCTGGACGCGCTACGGGCACATTTAG
GGCAAGGGGAGGCGCAGGCGCAGCGCGGTGAGTTTGTCGAAAACTATTCCATCGAGGCGGTGATTACCGAGTTAGATCAG
GAAATCTGA

Structures

Toxin

• AlphaFold DB: D5BWT5

Antitoxin

• AlphaFold DB: D5BWT4