Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3639350..3640086 Replicon chromosome
Accession NZ_CP098131
Organism Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag NBY54_RS17645 Protein ID WP_032433360.1
Coordinates 3639604..3640086 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NBY54_RS17640 Protein ID WP_003026799.1
Coordinates 3639350..3639616 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY54_RS17615 (3634996) 3634996..3636135 + 1140 WP_032433368.1 mannitol dehydrogenase -
NBY54_RS17620 (3636164) 3636164..3636826 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
NBY54_RS17625 (3636807) 3636807..3637814 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
NBY54_RS17630 (3637832) 3637832..3638464 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
NBY54_RS17635 (3638474) 3638474..3639037 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
NBY54_RS17640 (3639350) 3639350..3639616 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NBY54_RS17645 (3639604) 3639604..3640086 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
NBY54_RS17650 (3640447) 3640447..3641046 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
NBY54_RS17655 (3641259) 3641259..3642203 - 945 WP_077254249.1 fimbrial protein -
NBY54_RS17660 (3642215) 3642215..3642793 - 579 WP_032432061.1 type 1 fimbrial protein -
NBY54_RS17665 (3642797) 3642797..3643537 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3607295..3651029 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T246647 WP_032433360.1 NZ_CP098131:3639604-3640086 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT246647 WP_003026799.1 NZ_CP098131:3639350-3639616 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References