Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3622659..3623302 Replicon chromosome
Accession NZ_CP098131
Organism Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag NBY54_RS17550 Protein ID WP_032433387.1
Coordinates 3622886..3623302 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NBY54_RS17545 Protein ID WP_001261276.1
Coordinates 3622659..3622889 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY54_RS17530 (3617681) 3617681..3618768 + 1088 Protein_3404 transcriptional repressor PifC -
NBY54_RS17535 (3618771) 3618771..3621011 + 2241 WP_045326788.1 P-loop NTPase fold protein -
NBY54_RS17540 (3621539) 3621539..3622354 - 816 WP_032433388.1 hypothetical protein -
NBY54_RS17545 (3622659) 3622659..3622889 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NBY54_RS17550 (3622886) 3622886..3623302 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY54_RS17555 (3623458) 3623458..3624438 + 981 WP_032433385.1 hypothetical protein -
NBY54_RS17560 (3624633) 3624633..3626204 - 1572 WP_032433383.1 AAA family ATPase -
NBY54_RS17565 (3626523) 3626523..3626771 + 249 WP_032433382.1 hypothetical protein -
NBY54_RS17570 (3626830) 3626830..3627348 + 519 WP_045326794.1 hypothetical protein -
NBY54_RS17575 (3627379) 3627379..3627870 + 492 WP_032433378.1 hypothetical protein -
NBY54_RS17580 (3627930) 3627930..3628133 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3607295..3651029 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T246646 WP_032433387.1 NZ_CP098131:3622886-3623302 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT246646 WP_001261276.1 NZ_CP098131:3622659-3622889 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References