Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2991015..2991672 Replicon chromosome
Accession NZ_CP098131
Organism Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY54_RS14475 Protein ID WP_002916310.1
Coordinates 2991262..2991672 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY54_RS14470 Protein ID WP_002916312.1
Coordinates 2991015..2991281 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY54_RS14445 (2986171) 2986171..2987604 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NBY54_RS14450 (2987723) 2987723..2988451 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY54_RS14455 (2988501) 2988501..2988812 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY54_RS14460 (2988976) 2988976..2989635 + 660 WP_002916317.1 hemolysin III family protein -
NBY54_RS14465 (2989786) 2989786..2990769 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NBY54_RS14470 (2991015) 2991015..2991281 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY54_RS14475 (2991262) 2991262..2991672 + 411 WP_002916310.1 protein YgfX Toxin
NBY54_RS14480 (2991679) 2991679..2992200 - 522 WP_004144730.1 flavodoxin FldB -
NBY54_RS14485 (2992301) 2992301..2993197 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY54_RS14490 (2993220) 2993220..2993933 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY54_RS14495 (2993939) 2993939..2995672 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246645 WP_002916310.1 NZ_CP098131:2991262-2991672 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246645 WP_002916312.1 NZ_CP098131:2991015-2991281 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References