Detailed information of TA system TA246641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1735513..1737194
• Replicon: chromosome
• Accession: NZ_CP098131
• Organism: Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: NBY54_RS08310
• Protein ID: WP_015959269.1
• Coordinates: 1735513..1736388 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NBY54_RS08315
• Protein ID: WP_004177809.1
• Coordinates: 1736436..1737194 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY54_RS08290 (1730819)	1730819..1732339	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
NBY54_RS08295 (1732336)	1732336..1733334	+	999	WP_002885172.1	ribose ABC transporter permease	-
NBY54_RS08300 (1733365)	1733365..1734306	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
NBY54_RS08305 (1734381)	1734381..1735388	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
NBY54_RS08310 (1735513)	1735513..1736388	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NBY54_RS08315 (1736436)	1736436..1737194	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NBY54_RS08320 (1737280)	1737280..1738008	-	729	WP_032413197.1	response regulator transcription factor	-
NBY54_RS08325 (1738281)	1738281..1740428	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NBY54_RS08330 (1740425)	1740425..1740568	-	144	WP_162897205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T246641 WP_015959269.1 NZ_CP098131:c1736388-1735513 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT246641 WP_004177809.1 NZ_CP098131:c1737194-1736436 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05