Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1574326..1574842 Replicon chromosome
Accession NZ_CP098131
Organism Klebsiella pneumoniae strain Z0117KP0028

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NBY54_RS07485 Protein ID WP_009486548.1
Coordinates 1574326..1574610 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NBY54_RS07490 Protein ID WP_002886901.1
Coordinates 1574600..1574842 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY54_RS07460 (1569743) 1569743..1570051 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
NBY54_RS07465 (1570136) 1570136..1570309 + 174 WP_032433782.1 hypothetical protein -
NBY54_RS07470 (1570312) 1570312..1571055 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY54_RS07475 (1571412) 1571412..1573550 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY54_RS07480 (1573858) 1573858..1574322 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY54_RS07485 (1574326) 1574326..1574610 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY54_RS07490 (1574600) 1574600..1574842 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY54_RS07495 (1574920) 1574920..1576830 - 1911 WP_009486549.1 PRD domain-containing protein -
NBY54_RS07500 (1576853) 1576853..1578007 - 1155 WP_002886900.1 lactonase family protein -
NBY54_RS07505 (1578074) 1578074..1578814 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T246640 WP_009486548.1 NZ_CP098131:c1574610-1574326 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT246640 WP_002886901.1 NZ_CP098131:c1574842-1574600 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References