Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 9114..10024 | Replicon | chromosome |
| Accession | NZ_CP098131 | ||
| Organism | Klebsiella pneumoniae strain Z0117KP0028 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | NBY54_RS00050 | Protein ID | WP_004181896.1 |
| Coordinates | 9114..9584 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | NBY54_RS00055 | Protein ID | WP_004181895.1 |
| Coordinates | 9581..10024 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY54_RS00025 (4610) | 4610..4987 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| NBY54_RS00030 (5185) | 5185..6159 | - | 975 | WP_014386572.1 | hypothetical protein | - |
| NBY54_RS00035 (6762) | 6762..6920 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| NBY54_RS00040 (6992) | 6992..8173 | + | 1182 | WP_004883380.1 | IS481 family transposase | - |
| NBY54_RS00045 (8744) | 8744..9004 | + | 261 | WP_094966026.1 | hypothetical protein | - |
| NBY54_RS00050 (9114) | 9114..9584 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| NBY54_RS00055 (9581) | 9581..10024 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| NBY54_RS00060 (10125) | 10125..11392 | - | 1268 | Protein_11 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NBY54_RS00065 (11392) | 11392..11817 | - | 426 | Protein_12 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NBY54_RS00070 (11903) | 11903..13390 | - | 1488 | Protein_13 | group II intron reverse transcriptase/maturase | - |
| NBY54_RS00075 (14004) | 14004..14246 | + | 243 | WP_002901096.1 | DinI family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 6992..8173 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T246637 WP_004181896.1 NZ_CP098131:c9584-9114 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT246637 WP_004181895.1 NZ_CP098131:c10024-9581 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |