246633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3765968..3766611 Replicon chromosome
Accession NZ_CP098128
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag NBY56_RS19690 Protein ID WP_032433387.1
Coordinates 3765968..3766384 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NBY56_RS19695 Protein ID WP_001261276.1
Coordinates 3766381..3766611 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS19660 (3761137) 3761137..3761340 - 204 WP_032433376.1 HHA domain-containing protein -
NBY56_RS19665 (3761400) 3761400..3761891 - 492 WP_032433378.1 hypothetical protein -
NBY56_RS19670 (3761922) 3761922..3762440 - 519 WP_045326794.1 hypothetical protein -
NBY56_RS19675 (3762499) 3762499..3762747 - 249 WP_032433382.1 hypothetical protein -
NBY56_RS19680 (3763066) 3763066..3764637 + 1572 WP_032433383.1 AAA family ATPase -
NBY56_RS19685 (3764832) 3764832..3765812 - 981 WP_032433385.1 hypothetical protein -
NBY56_RS19690 (3765968) 3765968..3766384 - 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY56_RS19695 (3766381) 3766381..3766611 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NBY56_RS19700 (3766916) 3766916..3767731 + 816 WP_032433388.1 hypothetical protein -
NBY56_RS19705 (3768259) 3768259..3770499 - 2241 WP_045326788.1 P-loop NTPase fold protein -
NBY56_RS19710 (3770502) 3770502..3771589 - 1088 Protein_3575 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3736332..3781975 45643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T246633 WP_032433387.1 NZ_CP098128:c3766384-3765968 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT246633 WP_001261276.1 NZ_CP098128:c3766611-3766381 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References