246632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3749184..3749920 Replicon chromosome
Accession NZ_CP098128
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag NBY56_RS19595 Protein ID WP_032433360.1
Coordinates 3749184..3749666 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NBY56_RS19600 Protein ID WP_003026799.1
Coordinates 3749654..3749920 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS19575 (3745733) 3745733..3746473 + 741 WP_050597964.1 molecular chaperone -
NBY56_RS19580 (3746477) 3746477..3747055 + 579 WP_032432061.1 type 1 fimbrial protein -
NBY56_RS19585 (3747067) 3747067..3748011 + 945 WP_077254249.1 fimbrial protein -
NBY56_RS19590 (3748224) 3748224..3748823 + 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
NBY56_RS19595 (3749184) 3749184..3749666 - 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
NBY56_RS19600 (3749654) 3749654..3749920 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NBY56_RS19605 (3750233) 3750233..3750796 - 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
NBY56_RS19610 (3750806) 3750806..3751438 - 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
NBY56_RS19615 (3751456) 3751456..3752463 - 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
NBY56_RS19620 (3752444) 3752444..3753106 - 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
NBY56_RS19625 (3753135) 3753135..3754274 - 1140 WP_032433368.1 mannitol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3736332..3781975 45643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T246632 WP_032433360.1 NZ_CP098128:c3749666-3749184 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT246632 WP_003026799.1 NZ_CP098128:c3749920-3749654 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References