Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2555017..2556605 Replicon chromosome
Accession NZ_CP098128
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NBY56_RS13635 Protein ID WP_002904792.1
Coordinates 2555283..2556605 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NBY56_RS13630 Protein ID WP_002904790.1
Coordinates 2555017..2555283 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS13605 (2550047) 2550047..2550970 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
NBY56_RS13610 (2550951) 2550951..2552105 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY56_RS13615 (2552451) 2552451..2553830 + 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
NBY56_RS13620 (2553808) 2553808..2554308 + 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY56_RS13625 (2554305) 2554305..2554631 + 327 WP_002904788.1 hydroxyisourate hydrolase -
NBY56_RS13630 (2555017) 2555017..2555283 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY56_RS13635 (2555283) 2555283..2556605 + 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY56_RS13640 (2556622) 2556622..2557914 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY56_RS13645 (2558056) 2558056..2559060 - 1005 WP_032433097.1 fimbrial protein -
NBY56_RS13650 (2559048) 2559048..2561549 - 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T246627 WP_002904792.1 NZ_CP098128:2555283-2556605 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT246627 WP_002904790.1 NZ_CP098128:2555017-2555283 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References