Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 646590..647400 Replicon chromosome
Accession NZ_CP098128
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NBY56_RS04465 Protein ID WP_002887280.1
Coordinates 646867..647400 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NBY56_RS04460 Protein ID WP_002887278.1
Coordinates 646590..646856 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS04440 (642500) 642500..642805 - 306 WP_032432083.1 cation efflux system protein CusF -
NBY56_RS04445 (642823) 642823..644208 - 1386 WP_032431458.1 efflux transporter outer membrane subunit -
NBY56_RS04450 (644381) 644381..645064 + 684 WP_032105399.1 copper response regulator transcription factor CusR -
NBY56_RS04455 (645054) 645054..646487 + 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
NBY56_RS04460 (646590) 646590..646856 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NBY56_RS04465 (646867) 646867..647400 + 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NBY56_RS04470 (647447) 647447..648568 - 1122 WP_009309849.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T246625 WP_002887280.1 NZ_CP098128:646867-647400 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT246625 WP_002887278.1 NZ_CP098128:646590-646856 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References