246624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 536897..537413 Replicon chromosome
Accession NZ_CP098128
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NBY56_RS03995 Protein ID WP_009486548.1
Coordinates 537129..537413 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NBY56_RS03990 Protein ID WP_002886901.1
Coordinates 536897..537139 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS03975 (532925) 532925..533665 + 741 WP_009486551.1 KDGP aldolase family protein -
NBY56_RS03980 (533732) 533732..534886 + 1155 WP_002886900.1 lactonase family protein -
NBY56_RS03985 (534909) 534909..536819 + 1911 WP_009486549.1 PRD domain-containing protein -
NBY56_RS03990 (536897) 536897..537139 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY56_RS03995 (537129) 537129..537413 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY56_RS04000 (537417) 537417..537881 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY56_RS04005 (538189) 538189..540327 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY56_RS04010 (540684) 540684..541427 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY56_RS04015 (541430) 541430..541603 - 174 WP_032433782.1 hypothetical protein -
NBY56_RS04020 (541733) 541733..541996 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T246624 WP_009486548.1 NZ_CP098128:537129-537413 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT246624 WP_002886901.1 NZ_CP098128:536897-537139 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References