Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 374545..376226 | Replicon | chromosome |
| Accession | NZ_CP098128 | ||
| Organism | Klebsiella pneumoniae strain Z0117KP0033 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A6TH06 |
| Locus tag | NBY56_RS03170 | Protein ID | WP_015959269.1 |
| Coordinates | 375351..376226 (+) | Length | 292 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | NBY56_RS03165 | Protein ID | WP_004177809.1 |
| Coordinates | 374545..375303 (+) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY56_RS03145 (369574) | 369574..370937 | + | 1364 | WP_085955203.1 | IS3-like element ISKpn1 family transposase | - |
| NBY56_RS03150 (371171) | 371171..371314 | + | 144 | WP_162897205.1 | hypothetical protein | - |
| NBY56_RS03155 (371311) | 371311..373458 | - | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| NBY56_RS03160 (373731) | 373731..374459 | + | 729 | WP_032413197.1 | response regulator transcription factor | - |
| NBY56_RS03165 (374545) | 374545..375303 | + | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| NBY56_RS03170 (375351) | 375351..376226 | + | 876 | WP_015959269.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NBY56_RS03175 (376351) | 376351..377358 | - | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| NBY56_RS03180 (377433) | 377433..378374 | - | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| NBY56_RS03185 (378405) | 378405..379403 | - | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| NBY56_RS03190 (379400) | 379400..380920 | - | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 292 a.a. Molecular weight: 32990.17 Da Isoelectric Point: 5.4637
>T246623 WP_015959269.1 NZ_CP098128:375351-376226 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 876 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT246623 WP_004177809.1 NZ_CP098128:374545-375303 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|