Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 129437..130188 Replicon plasmid pZ0117KP0033-1
Accession NZ_CP098127
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag NBY56_RS00710 Protein ID WP_014386536.1
Coordinates 129706..130188 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NBY56_RS00705 Protein ID WP_004902250.1
Coordinates 129437..129715 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS00670 (NBY56_00670) 125080..125505 - 426 WP_000522996.1 organomercurial transporter MerC -
NBY56_RS00675 (NBY56_00675) 125533..125808 - 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
NBY56_RS00680 (NBY56_00680) 125824..126189 - 366 WP_001294656.1 mercuric ion transporter MerT -
NBY56_RS00685 (NBY56_00685) 126261..126716 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
NBY56_RS00690 (NBY56_00690) 127369..127827 + 459 WP_014386535.1 hypothetical protein -
NBY56_RS00695 (NBY56_00695) 128657..128998 + 342 WP_004902257.1 hypothetical protein -
NBY56_RS00700 (NBY56_00700) 129106..129318 + 213 WP_004902255.1 hypothetical protein -
NBY56_RS00705 (NBY56_00705) 129437..129715 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NBY56_RS00710 (NBY56_00710) 129706..130188 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
NBY56_RS00715 (NBY56_00715) 131223..131762 + 540 WP_004902239.1 hypothetical protein -
NBY56_RS00720 (NBY56_00720) 131867..132259 + 393 WP_032442757.1 hypothetical protein -
NBY56_RS00725 (NBY56_00725) 132360..133115 + 756 WP_004902235.1 DUF2971 domain-containing protein -
NBY56_RS00730 (NBY56_00730) 133142..133789 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-Ib-cr / ARR-3 / qacE / sul1 / qnrB4 / blaDHA-1 / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(A) - 1..265595 265595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T246620 WP_014386536.1 NZ_CP098127:129706-130188 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT246620 WP_004902250.1 NZ_CP098127:129437-129715 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References