246619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 68682..69204 Replicon plasmid pZ0117KP0033-1
Accession NZ_CP098127
Organism Klebsiella pneumoniae strain Z0117KP0033

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag NBY56_RS00335 Protein ID WP_004181778.1
Coordinates 68682..68966 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag NBY56_RS00340 Protein ID WP_004181777.1
Coordinates 68956..69204 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY56_RS00300 (NBY56_00300) 64320..64664 + 345 WP_223811496.1 hypothetical protein -
NBY56_RS00305 (NBY56_00305) 64661..65032 + 372 WP_040209644.1 hypothetical protein -
NBY56_RS00310 (NBY56_00310) 65077..66264 - 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
NBY56_RS00315 (NBY56_00315) 66300..66728 + 429 WP_077257669.1 IS200/IS605 family transposase -
NBY56_RS00320 (NBY56_00320) 66807..67031 + 225 Protein_64 transposase -
NBY56_RS00325 (NBY56_00325) 67302..68528 - 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
NBY56_RS00330 (NBY56_00330) 68564..68665 + 102 Protein_66 IS200/IS605 family transposase -
NBY56_RS00335 (NBY56_00335) 68682..68966 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY56_RS00340 (NBY56_00340) 68956..69204 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NBY56_RS00345 (NBY56_00345) 69495..71294 + 1800 WP_004181776.1 ATP-dependent helicase -
NBY56_RS00350 (NBY56_00350) 71628..72614 + 987 WP_094965947.1 hypothetical protein -
NBY56_RS00355 (NBY56_00355) 72759..73112 + 354 WP_004181774.1 hypothetical protein -
NBY56_RS00360 (NBY56_00360) 73174..73995 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-Ib-cr / ARR-3 / qacE / sul1 / qnrB4 / blaDHA-1 / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(A) - 1..265595 265595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T246619 WP_004181778.1 NZ_CP098127:c68966-68682 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT246619 WP_004181777.1 NZ_CP098127:c69204-68956 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References