Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4741538..4742054 Replicon chromosome
Accession NZ_CP098123
Organism Klebsiella pneumoniae strain Z0117KP0042

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NBY58_RS23205 Protein ID WP_009486548.1
Coordinates 4741538..4741822 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NBY58_RS23210 Protein ID WP_002886901.1
Coordinates 4741812..4742054 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY58_RS23180 (4736955) 4736955..4737218 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NBY58_RS23185 (4737348) 4737348..4737521 + 174 WP_032433782.1 hypothetical protein -
NBY58_RS23190 (4737524) 4737524..4738267 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY58_RS23195 (4738624) 4738624..4740762 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY58_RS23200 (4741070) 4741070..4741534 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY58_RS23205 (4741538) 4741538..4741822 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY58_RS23210 (4741812) 4741812..4742054 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY58_RS23215 (4742132) 4742132..4744042 - 1911 WP_009486549.1 PRD domain-containing protein -
NBY58_RS23220 (4744065) 4744065..4745219 - 1155 WP_002886900.1 lactonase family protein -
NBY58_RS23225 (4745286) 4745286..4746026 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T246616 WP_009486548.1 NZ_CP098123:c4741822-4741538 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT246616 WP_002886901.1 NZ_CP098123:c4742054-4741812 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References