Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1530912..1531648 Replicon chromosome
Accession NZ_CP098123
Organism Klebsiella pneumoniae strain Z0117KP0042

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag NBY58_RS07600 Protein ID WP_032433360.1
Coordinates 1531166..1531648 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag NBY58_RS07595 Protein ID WP_003026799.1
Coordinates 1530912..1531178 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY58_RS07570 (1526558) 1526558..1527697 + 1140 WP_032433368.1 mannitol dehydrogenase -
NBY58_RS07575 (1527726) 1527726..1528388 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
NBY58_RS07580 (1528369) 1528369..1529376 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
NBY58_RS07585 (1529394) 1529394..1530026 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
NBY58_RS07590 (1530036) 1530036..1530599 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
NBY58_RS07595 (1530912) 1530912..1531178 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
NBY58_RS07600 (1531166) 1531166..1531648 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
NBY58_RS07605 (1532009) 1532009..1532608 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
NBY58_RS07610 (1532821) 1532821..1533765 - 945 WP_077254249.1 fimbrial protein -
NBY58_RS07615 (1533777) 1533777..1534355 - 579 WP_032432061.1 type 1 fimbrial protein -
NBY58_RS07620 (1534359) 1534359..1535099 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1498857..1542591 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T246608 WP_032433360.1 NZ_CP098123:1531166-1531648 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT246608 WP_003026799.1 NZ_CP098123:1530912-1531178 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References