Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1514221..1514864 Replicon chromosome
Accession NZ_CP098123
Organism Klebsiella pneumoniae strain Z0117KP0042

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag NBY58_RS07505 Protein ID WP_032433387.1
Coordinates 1514448..1514864 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NBY58_RS07500 Protein ID WP_001261276.1
Coordinates 1514221..1514451 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY58_RS07485 (1509243) 1509243..1510330 + 1088 Protein_1463 transcriptional repressor PifC -
NBY58_RS07490 (1510333) 1510333..1512573 + 2241 WP_045326788.1 P-loop NTPase fold protein -
NBY58_RS07495 (1513101) 1513101..1513916 - 816 WP_032433388.1 hypothetical protein -
NBY58_RS07500 (1514221) 1514221..1514451 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NBY58_RS07505 (1514448) 1514448..1514864 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY58_RS07510 (1515020) 1515020..1516000 + 981 WP_032433385.1 hypothetical protein -
NBY58_RS07515 (1516195) 1516195..1517766 - 1572 WP_032433383.1 AAA family ATPase -
NBY58_RS07520 (1518085) 1518085..1518333 + 249 WP_032433382.1 hypothetical protein -
NBY58_RS07525 (1518392) 1518392..1518910 + 519 WP_045326794.1 hypothetical protein -
NBY58_RS07530 (1518941) 1518941..1519432 + 492 WP_032433378.1 hypothetical protein -
NBY58_RS07535 (1519492) 1519492..1519695 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1498857..1542591 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T246607 WP_032433387.1 NZ_CP098123:1514448-1514864 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT246607 WP_001261276.1 NZ_CP098123:1514221-1514451 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References