Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 882576..883233 Replicon chromosome
Accession NZ_CP098123
Organism Klebsiella pneumoniae strain Z0117KP0042

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY58_RS04435 Protein ID WP_002916310.1
Coordinates 882823..883233 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY58_RS04430 Protein ID WP_002916312.1
Coordinates 882576..882842 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY58_RS04405 (877732) 877732..879165 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NBY58_RS04410 (879284) 879284..880012 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY58_RS04415 (880062) 880062..880373 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY58_RS04420 (880537) 880537..881196 + 660 WP_002916317.1 hemolysin III family protein -
NBY58_RS04425 (881347) 881347..882330 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NBY58_RS04430 (882576) 882576..882842 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY58_RS04435 (882823) 882823..883233 + 411 WP_002916310.1 protein YgfX Toxin
NBY58_RS04440 (883240) 883240..883761 - 522 WP_004144730.1 flavodoxin FldB -
NBY58_RS04445 (883862) 883862..884758 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY58_RS04450 (884781) 884781..885494 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY58_RS04455 (885500) 885500..887233 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246606 WP_002916310.1 NZ_CP098123:882823-883233 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246606 WP_002916312.1 NZ_CP098123:882576-882842 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References