Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4271383..4272031 Replicon chromosome
Accession NZ_CP098040
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L3Q80_RS20065 Protein ID WP_094961724.1
Coordinates 4271846..4272031 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L3Q80_RS20060 Protein ID WP_181489706.1
Coordinates 4271383..4271796 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS20035 (L3Q80_20025) 4266741..4267658 - 918 WP_181488164.1 oxygen-dependent coproporphyrinogen oxidase -
L3Q80_RS20040 (L3Q80_20030) 4267795..4268226 + 432 WP_181488162.1 GNAT family acetyltransferase -
L3Q80_RS20050 (L3Q80_20040) 4269648..4270175 + 528 WP_282561954.1 RpoE-regulated lipoprotein -
L3Q80_RS20055 (L3Q80_20045) 4270418..4271317 + 900 WP_094961722.1 Dyp-type peroxidase -
L3Q80_RS20060 (L3Q80_20050) 4271383..4271796 - 414 WP_181489706.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L3Q80_RS20065 (L3Q80_20055) 4271846..4272031 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
L3Q80_RS20070 (L3Q80_20060) 4272354..4273376 + 1023 WP_094961725.1 sulfate ABC transporter substrate-binding protein -
L3Q80_RS20075 (L3Q80_20065) 4273376..4274206 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
L3Q80_RS20080 (L3Q80_20070) 4274206..4275066 + 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
L3Q80_RS20085 (L3Q80_20075) 4275069..4276157 + 1089 WP_004264880.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T246601 WP_094961724.1 NZ_CP098040:c4272031-4271846 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15361.32 Da        Isoelectric Point: 4.5725

>AT246601 WP_181489706.1 NZ_CP098040:c4271796-4271383 [Providencia rettgeri]
MLYTAFIEIDDDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQALLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAVAARKELKKTD

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References