Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3345042..3345688 Replicon chromosome
Accession NZ_CP098040
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag L3Q80_RS15785 Protein ID WP_004905417.1
Coordinates 3345042..3345245 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag L3Q80_RS15790 Protein ID WP_004905413.1
Coordinates 3345320..3345688 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS15760 (L3Q80_15750) 3341118..3341456 + 339 WP_004905421.1 P-II family nitrogen regulator -
L3Q80_RS15765 (L3Q80_15755) 3341506..3342753 + 1248 WP_164456268.1 ammonium transporter AmtB -
L3Q80_RS15770 (L3Q80_15760) 3342892..3343761 - 870 WP_181489678.1 acyl-CoA thioesterase II -
L3Q80_RS15775 (L3Q80_15765) 3344000..3344458 + 459 WP_004905418.1 YbaY family lipoprotein -
L3Q80_RS15785 (L3Q80_15775) 3345042..3345245 - 204 WP_004905417.1 HHA domain-containing protein Toxin
L3Q80_RS15790 (L3Q80_15780) 3345320..3345688 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
L3Q80_RS15795 (L3Q80_15785) 3346212..3347582 - 1371 WP_094962148.1 murein transglycosylase D -
L3Q80_RS15800 (L3Q80_15790) 3347664..3348419 - 756 WP_004905408.1 hydroxyacylglutathione hydrolase -
L3Q80_RS15805 (L3Q80_15795) 3348460..3349194 + 735 WP_094962149.1 methyltransferase domain-containing protein -
L3Q80_RS15810 (L3Q80_15800) 3349191..3349661 - 471 WP_004905405.1 ribonuclease HI -
L3Q80_RS15815 (L3Q80_15805) 3349716..3350477 + 762 WP_094962150.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaCTX-M-3 / mph(E) / msr(E) - 3034044..3346031 311987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T246599 WP_004905417.1 NZ_CP098040:c3345245-3345042 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT246599 WP_004905413.1 NZ_CP098040:c3345688-3345320 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References