Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2201684..2203260 Replicon chromosome
Accession NZ_CP098040
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L3Q80_RS10560 Protein ID WP_140172675.1
Coordinates 2201941..2203260 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L3Q80_RS10555 Protein ID WP_036959176.1
Coordinates 2201684..2201941 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS10530 (L3Q80_10525) 2197495..2197638 + 144 WP_004906236.1 50S ribosomal protein L34 -
L3Q80_RS10535 (L3Q80_10530) 2197660..2198019 + 360 WP_004906229.1 ribonuclease P protein component -
L3Q80_RS10540 (L3Q80_10535) 2197983..2198243 + 261 WP_036959180.1 membrane protein insertion efficiency factor YidD -
L3Q80_RS10545 (L3Q80_10540) 2198246..2199895 + 1650 WP_004906225.1 membrane protein insertase YidC -
L3Q80_RS10550 (L3Q80_10545) 2199997..2201361 + 1365 WP_004906223.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
L3Q80_RS10555 (L3Q80_10550) 2201684..2201941 + 258 WP_036959176.1 helix-turn-helix domain-containing protein Antitoxin
L3Q80_RS10560 (L3Q80_10555) 2201941..2203260 + 1320 WP_140172675.1 type II toxin-antitoxin system HipA family toxin Toxin
L3Q80_RS10565 (L3Q80_10560) 2203271..2204101 - 831 WP_094961979.1 formate dehydrogenase accessory sulfurtransferase FdhD -
L3Q80_RS10570 (L3Q80_10565) 2204276..2207323 + 3048 WP_282550878.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50013.00 Da        Isoelectric Point: 6.5676

>T246597 WP_140172675.1 NZ_CP098040:2201941-2203260 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPYSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVIKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.85 Da        Isoelectric Point: 9.6898

>AT246597 WP_036959176.1 NZ_CP098040:2201684-2201941 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References