Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1929845..1930430 Replicon chromosome
Accession NZ_CP098040
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag L3Q80_RS09205 Protein ID WP_004905874.1
Coordinates 1929845..1930162 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag L3Q80_RS09210 Protein ID WP_004905876.1
Coordinates 1930143..1930430 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS09175 (L3Q80_09170) 1925548..1925799 - 252 WP_094961642.1 DUF1471 domain-containing protein -
L3Q80_RS09180 (L3Q80_09175) 1926070..1926408 + 339 WP_004905864.1 GIY-YIG nuclease family protein -
L3Q80_RS09185 (L3Q80_09180) 1926381..1926884 - 504 WP_112308100.1 N-acetyltransferase -
L3Q80_RS09190 (L3Q80_09185) 1926878..1927402 - 525 WP_112308101.1 SCP2 domain-containing protein -
L3Q80_RS09195 (L3Q80_09190) 1927917..1928912 + 996 WP_094961644.1 peptidase U32 family protein -
L3Q80_RS09200 (L3Q80_09195) 1928930..1929805 + 876 WP_112308102.1 U32 family peptidase -
L3Q80_RS09205 (L3Q80_09200) 1929845..1930162 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
L3Q80_RS09210 (L3Q80_09205) 1930143..1930430 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L3Q80_RS09215 (L3Q80_09210) 1930561..1931715 - 1155 WP_004905877.1 ABC transporter permease -
L3Q80_RS09220 (L3Q80_09215) 1931715..1932860 - 1146 WP_004905879.1 ABC transporter permease -
L3Q80_RS09225 (L3Q80_09220) 1932872..1933843 - 972 WP_004905881.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T246596 WP_004905874.1 NZ_CP098040:c1930162-1929845 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT246596 WP_004905876.1 NZ_CP098040:c1930430-1930143 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References