Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 767840..768375 Replicon chromosome
Accession NZ_CP098040
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag L3Q80_RS03755 Protein ID WP_144141264.1
Coordinates 768067..768375 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D4BV21
Locus tag L3Q80_RS03750 Protein ID WP_004255691.1
Coordinates 767840..768067 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS03730 (L3Q80_03725) 763123..763563 + 441 WP_004255682.1 flagellar export chaperone FlgN -
L3Q80_RS03740 (L3Q80_03735) 764333..766432 - 2100 WP_004255687.1 flagellar biosynthesis protein FlhA -
L3Q80_RS03745 (L3Q80_03740) 766425..767576 - 1152 WP_140170721.1 flagellar biosynthesis protein FlhB -
L3Q80_RS03750 (L3Q80_03745) 767840..768067 + 228 WP_004255691.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L3Q80_RS03755 (L3Q80_03750) 768067..768375 + 309 WP_144141264.1 CcdB family protein Toxin
L3Q80_RS03760 (L3Q80_03755) 768391..768948 + 558 WP_144141262.1 hypothetical protein -
L3Q80_RS03765 (L3Q80_03760) 768991..769197 - 207 WP_272661075.1 helix-turn-helix transcriptional regulator -
L3Q80_RS03770 (L3Q80_03765) 769395..770033 - 639 WP_094961165.1 protein phosphatase CheZ -
L3Q80_RS03775 (L3Q80_03770) 770058..770450 - 393 WP_004255705.1 chemotaxis response regulator CheY -
L3Q80_RS03780 (L3Q80_03775) 770492..771559 - 1068 WP_094961164.1 chemotaxis response regulator protein-glutamate methylesterase -
L3Q80_RS03785 (L3Q80_03780) 771559..772395 - 837 WP_094961163.1 CheR family methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11757.87 Da        Isoelectric Point: 8.0469

>T246594 WP_144141264.1 NZ_CP098040:768067-768375 [Providencia rettgeri]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPARLTPQLVINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8688.92 Da        Isoelectric Point: 8.9375

>AT246594 WP_004255691.1 NZ_CP098040:767840-768067 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q922

References