Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 251666..252582 Replicon chromosome
Accession NZ_CP098040
Organism Providencia rettgeri strain 18004577

Toxin (Protein)


Gene name - Uniprot ID D4BTW9
Locus tag L3Q80_RS01220 Protein ID WP_004254505.1
Coordinates 252124..252582 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag L3Q80_RS01215 Protein ID WP_181487862.1
Coordinates 251666..252127 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q80_RS01185 (L3Q80_01180) 247329..247943 + 615 WP_004254484.1 LysE family translocator -
L3Q80_RS01190 (L3Q80_01185) 247973..248446 - 474 WP_036957747.1 NUDIX domain-containing protein -
L3Q80_RS01195 (L3Q80_01190) 248798..249439 - 642 WP_004254492.1 leucine efflux protein LeuE -
L3Q80_RS01200 (L3Q80_01195) 249949..250611 + 663 WP_282553829.1 AzlC family ABC transporter permease -
L3Q80_RS01205 (L3Q80_01200) 250608..250922 + 315 WP_094960595.1 AzlD domain-containing protein -
L3Q80_RS01210 (L3Q80_01205) 251110..251577 + 468 WP_036957750.1 DUF1456 family protein -
L3Q80_RS01215 (L3Q80_01210) 251666..252127 + 462 WP_181487862.1 DUF2384 domain-containing protein Antitoxin
L3Q80_RS01220 (L3Q80_01215) 252124..252582 + 459 WP_004254505.1 RES domain-containing protein Toxin
L3Q80_RS01225 (L3Q80_01220) 252583..253473 - 891 WP_094960598.1 LysR family transcriptional regulator -
L3Q80_RS01230 (L3Q80_01225) 253519..254478 - 960 WP_094960599.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
L3Q80_RS01235 (L3Q80_01230) 254584..254934 - 351 WP_232368671.1 MerR family DNA-binding protein -
L3Q80_RS01240 (L3Q80_01235) 255035..255562 - 528 WP_036957752.1 GNAT family N-acetyltransferase -
L3Q80_RS01245 (L3Q80_01240) 255579..257045 - 1467 WP_112307052.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-145)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17088.65 Da        Isoelectric Point: 6.2048

>T246593 WP_004254505.1 NZ_CP098040:252124-252582 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDILLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Download         Length: 459 bp

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17086.58 Da        Isoelectric Point: 9.9140

>AT246593 WP_181487862.1 NZ_CP098040:251666-252127 [Providencia rettgeri]
MRNYIPTPPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4BTW9

Antitoxin

Source ID Structure

References