246592

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1359948..1360864 Replicon chromosome
Accession NZ_CP098036
Organism Bacillus subtilis strain SPC-17-3

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NBY72_RS07220 Protein ID WP_003244695.1
Coordinates 1360118..1360864 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NBY72_RS07215 Protein ID WP_003232646.1
Coordinates 1359948..1360118 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY72_RS07180 (NBY72_07180) 1356807..1357136 + 330 WP_014479562.1 XkdW family protein -
NBY72_RS07185 (NBY72_07185) 1357133..1357297 + 165 WP_014479563.1 XkdX family protein -
NBY72_RS07190 (NBY72_07190) 1357344..1358183 + 840 WP_014479564.1 phage-like element PBSX protein XepA -
NBY72_RS07195 (NBY72_07195) 1358236..1358505 + 270 WP_014479565.1 hemolysin XhlA family protein -
NBY72_RS07200 (NBY72_07200) 1358518..1358781 + 264 WP_014479566.1 phage holin -
NBY72_RS07205 (NBY72_07205) 1358794..1359687 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
NBY72_RS07210 (NBY72_07210) 1359725..1359862 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NBY72_RS07215 (NBY72_07215) 1359948..1360118 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NBY72_RS07220 (NBY72_07220) 1360118..1360864 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NBY72_RS07225 (NBY72_07225) 1360974..1361975 - 1002 WP_014479569.1 inorganic phosphate transporter -
NBY72_RS07230 (NBY72_07230) 1361988..1362605 - 618 WP_003218470.1 DUF47 domain-containing protein -
NBY72_RS07235 (NBY72_07235) 1362881..1364197 - 1317 WP_014479570.1 serine/threonine exchanger -
NBY72_RS07240 (NBY72_07240) 1364586..1365536 + 951 WP_014479571.1 ring-cleaving dioxygenase -
NBY72_RS07245 (NBY72_07245) 1365645..1365740 + 96 Protein_1365 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T246592 WP_003244695.1 NZ_CP098036:c1360864-1360118 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT246592 WP_003232646.1 NZ_CP098036:c1360118-1359948 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References