Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 4305912..4306635 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NAL25_RS20595 Protein ID WP_095099094.1
Coordinates 4305912..4306298 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NAL25_RS20600 Protein ID WP_046899002.1
Coordinates 4306291..4306635 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS20570 (NAL25_20545) 4301218..4301607 - 390 WP_257711362.1 DUF3224 domain-containing protein -
NAL25_RS20575 (NAL25_20550) 4301843..4302682 + 840 WP_257711364.1 helix-turn-helix domain-containing protein -
NAL25_RS20585 (NAL25_20560) 4303022..4304539 - 1518 WP_004931697.1 lysine--tRNA ligase -
NAL25_RS20595 (NAL25_20570) 4305912..4306298 + 387 WP_095099094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NAL25_RS20600 (NAL25_20575) 4306291..4306635 + 345 WP_046899002.1 helix-turn-helix domain-containing protein Antitoxin
NAL25_RS20605 (NAL25_20580) 4306687..4308420 - 1734 WP_033639478.1 single-stranded-DNA-specific exonuclease RecJ -
NAL25_RS20610 (NAL25_20585) 4308427..4309143 - 717 WP_042785306.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NAL25_RS20615 (NAL25_20590) 4309170..4310069 - 900 WP_033644935.1 site-specific tyrosine recombinase XerD -
NAL25_RS20620 (NAL25_20595) 4310176..4310694 + 519 WP_257711372.1 flavodoxin FldB -
NAL25_RS20625 (NAL25_20600) 4310760..4311182 - 423 WP_046899001.1 protein YgfX -
NAL25_RS20630 (NAL25_20605) 4311163..4311429 - 267 WP_257711373.1 FAD assembly factor SdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14621.64 Da        Isoelectric Point: 8.4849

>T246583 WP_095099094.1 NZ_CP098030:4305912-4306298 [Serratia ureilytica]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELEHGNHDGDLGGGVYKKRLPLNRGKRGGARSIVAFKHGRHQYFVDGWLKNT
VKQNGAKEINDDELATYRELAKDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12927.88 Da        Isoelectric Point: 10.9886

>AT246583 WP_046899002.1 NZ_CP098030:4306291-4306635 [Serratia ureilytica]
MTDNRLLRLQKMAQRFNEIGAVSDDTMRSIDARVQAQEQNAQHEQREQMDGARIKMLRKRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGSALRMLEIIEQKGVASLIIPPRN

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References