Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3921101..3921757 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NAL25_RS18805 Protein ID WP_046897729.1
Coordinates 3921101..3921490 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NAL25_RS18810 Protein ID WP_019452401.1
Coordinates 3921494..3921757 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS18790 (NAL25_18770) 3917568..3918998 + 1431 WP_046897726.1 multidrug transporter subunit MdtD -
NAL25_RS18795 (NAL25_18775) 3918995..3920377 + 1383 WP_046897727.1 two-component system sensor histidine kinase BaeS -
NAL25_RS18800 (NAL25_18780) 3920377..3921093 + 717 WP_257711160.1 two-component system response regulator BaeR -
NAL25_RS18805 (NAL25_18785) 3921101..3921490 - 390 WP_046897729.1 type II toxin-antitoxin system VapC family toxin Toxin
NAL25_RS18810 (NAL25_18790) 3921494..3921757 - 264 WP_019452401.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NAL25_RS18815 (NAL25_18795) 3922095..3922433 + 339 WP_033644064.1 YegP family protein -
NAL25_RS18820 (NAL25_18800) 3922612..3923964 + 1353 WP_046897730.1 tRNA 5-hydroxyuridine modification protein YegQ -
NAL25_RS18825 (NAL25_18805) 3924181..3924402 - 222 WP_152665227.1 hypothetical protein -
NAL25_RS18830 (NAL25_18810) 3924432..3925337 + 906 WP_046897731.1 lipid kinase YegS -
NAL25_RS18835 (NAL25_18815) 3925598..3926647 + 1050 WP_015378749.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14336.56 Da        Isoelectric Point: 7.3214

>T246582 WP_046897729.1 NZ_CP098030:c3921490-3921101 [Serratia ureilytica]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTH

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10048.29 Da        Isoelectric Point: 4.6583

>AT246582 WP_019452401.1 NZ_CP098030:c3921757-3921494 [Serratia ureilytica]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEDE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References