Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3824968..3825530 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NAL25_RS18385 Protein ID WP_025303801.1
Coordinates 3824968..3825324 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag NAL25_RS18390 Protein ID WP_004936539.1
Coordinates 3825321..3825530 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS18365 (NAL25_18345) 3820709..3821500 - 792 WP_182265500.1 TonB family protein -
NAL25_RS18370 (NAL25_18350) 3821603..3822442 - 840 WP_257713199.1 ChaN family lipoprotein -
NAL25_RS18375 (NAL25_18355) 3822621..3824030 + 1410 WP_046896238.1 S-methylmethionine permease -
NAL25_RS18380 (NAL25_18360) 3824020..3824958 + 939 WP_046896237.1 homocysteine S-methyltransferase -
NAL25_RS18385 (NAL25_18365) 3824968..3825324 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NAL25_RS18390 (NAL25_18370) 3825321..3825530 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NAL25_RS18395 (NAL25_18375) 3825640..3827919 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
NAL25_RS18400 (NAL25_18380) 3828135..3828308 - 174 WP_004936544.1 hypothetical protein -
NAL25_RS18405 (NAL25_18385) 3828289..3828669 - 381 WP_046896236.1 DUF2570 family protein -
NAL25_RS18410 (NAL25_18390) 3828666..3829067 - 402 WP_182265501.1 M15 family metallopeptidase -
NAL25_RS18415 (NAL25_18395) 3829057..3829383 - 327 WP_033643982.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T246581 WP_025303801.1 NZ_CP098030:c3825324-3824968 [Serratia ureilytica]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT246581 WP_004936539.1 NZ_CP098030:c3825530-3825321 [Serratia ureilytica]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References