Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1585171..1585724 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag NAL25_RS07685 Protein ID WP_046896980.1
Coordinates 1585410..1585724 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2V4GJ62
Locus tag NAL25_RS07680 Protein ID WP_029988820.1
Coordinates 1585171..1585407 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS07665 (NAL25_07655) 1581637..1583172 + 1536 WP_004938996.1 glutathione ABC transporter substrate-binding protein GsiB -
NAL25_RS07670 (NAL25_07660) 1583225..1584145 + 921 WP_046896979.1 glutathione ABC transporter permease GsiC -
NAL25_RS07675 (NAL25_07665) 1584155..1585063 + 909 WP_193549762.1 glutathione ABC transporter permease GsiD -
NAL25_RS07680 (NAL25_07670) 1585171..1585407 + 237 WP_029988820.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NAL25_RS07685 (NAL25_07675) 1585410..1585724 + 315 WP_046896980.1 CcdB family protein Toxin
NAL25_RS07690 (NAL25_07680) 1585762..1586604 - 843 WP_015377214.1 S-formylglutathione hydrolase -
NAL25_RS07695 (NAL25_07685) 1586619..1587743 - 1125 WP_257713170.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
NAL25_RS07700 (NAL25_07690) 1587774..1588694 - 921 WP_046896982.1 LysR family transcriptional regulator -
NAL25_RS07705 (NAL25_07695) 1588800..1589957 + 1158 WP_257712827.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11644.57 Da        Isoelectric Point: 4.7085

>T246574 WP_046896980.1 NZ_CP098030:1585410-1585724 [Serratia ureilytica]
MQFTVYANSGNSAIYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSPRPERLIPLIKLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRSRIKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9082.13 Da        Isoelectric Point: 5.7070

>AT246574 WP_029988820.1 NZ_CP098030:1585171-1585407 [Serratia ureilytica]
MPVKQRTTQSVTMTLERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GJ62

References