Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14072..14673 Replicon chromosome
Accession NZ_CP098030
Organism Serratia ureilytica strain HNU47

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag NAL25_RS00065 Protein ID WP_025304766.1
Coordinates 14072..14452 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag NAL25_RS00070 Protein ID WP_025304767.1
Coordinates 14452..14673 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL25_RS00040 (NAL25_00040) 9319..10599 + 1281 WP_257712045.1 DUF3748 domain-containing protein -
NAL25_RS00045 (NAL25_00045) 10630..10977 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
NAL25_RS00050 (NAL25_00050) 11287..11700 + 414 WP_004933919.1 small heat shock chaperone IbpA -
NAL25_RS00055 (NAL25_00055) 11807..12235 + 429 WP_004933922.1 small heat shock chaperone IbpB -
NAL25_RS00060 (NAL25_00060) 12403..14061 + 1659 WP_046898766.1 putative transporter -
NAL25_RS00065 (NAL25_00065) 14072..14452 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
NAL25_RS00070 (NAL25_00070) 14452..14673 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
NAL25_RS00075 (NAL25_00075) 14749..15999 - 1251 WP_193550018.1 valine--pyruvate transaminase -
NAL25_RS00080 (NAL25_00080) 17014..17793 + 780 WP_182265610.1 2OG-Fe dioxygenase family protein -
NAL25_RS00085 (NAL25_00085) 17873..19012 + 1140 WP_046687995.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T246567 WP_025304766.1 NZ_CP098030:c14452-14072 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT246567 WP_025304767.1 NZ_CP098030:c14673-14452 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References