246566

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 39626..40763 Replicon plasmid pQZ076-3
Accession NZ_CP098028
Organism Enterococcus faecalis strain QZ076

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag NAG05_RS15625 Protein ID WP_250170996.1
Coordinates 39626..40489 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID B3CKC7
Locus tag NAG05_RS15630 Protein ID WP_002333002.1
Coordinates 40491..40763 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG05_RS15600 (35081) 35081..35425 + 345 Protein_39 IS30 family transposase -
NAG05_RS15605 (35497) 35497..37110 - 1614 WP_002333004.1 hypothetical protein -
NAG05_RS15610 (37134) 37134..38015 - 882 WP_002326774.1 ABC transporter ATP-binding protein -
NAG05_RS15615 (38326) 38326..38922 + 597 WP_085442989.1 TetR/AcrR family transcriptional regulator -
NAG05_RS15620 (39091) 39091..39495 - 405 Protein_43 DnaJ domain-containing protein -
NAG05_RS15625 (39626) 39626..40489 - 864 WP_250170996.1 zeta toxin family protein Toxin
NAG05_RS15630 (40491) 40491..40763 - 273 WP_002333002.1 antitoxin Antitoxin
NAG05_RS15635 (40781) 40781..40996 - 216 WP_001835296.1 peptide-binding protein -
NAG05_RS15640 (41088) 41088..41984 - 897 WP_002387620.1 ParA family protein -
NAG05_RS15645 (42087) 42087..43919 - 1833 WP_250652965.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrG / aph(3')-III / erm(B) - 1..55867 55867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32365.76 Da        Isoelectric Point: 6.3643

>T246566 WP_250170996.1 NZ_CP098028:c40489-39626 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 7.1987

>AT246566 WP_002333002.1 NZ_CP098028:c40763-40491 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z6BWJ3

References