Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 14827..15398 | Replicon | plasmid pQZ076-3 |
Accession | NZ_CP098028 | ||
Organism | Enterococcus faecalis strain QZ076 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A2Z2CGM4 |
Locus tag | NAG05_RS15480 | Protein ID | WP_002362432.1 |
Coordinates | 14827..15168 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | R3KHK9 |
Locus tag | NAG05_RS15485 | Protein ID | WP_002362431.1 |
Coordinates | 15168..15398 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NAG05_RS15455 (10887) | 10887..11282 | - | 396 | WP_002383639.1 | hypothetical protein | - |
NAG05_RS15460 (11239) | 11239..12561 | - | 1323 | Protein_11 | ATP-binding protein | - |
NAG05_RS15465 (12637) | 12637..13317 | + | 681 | WP_174087370.1 | IS6-like element IS1216 family transposase | - |
NAG05_RS15470 (13372) | 13372..13512 | - | 141 | Protein_13 | cell filamentation protein Fic | - |
NAG05_RS15475 (13777) | 13777..14715 | - | 939 | WP_002362433.1 | hypothetical protein | - |
NAG05_RS15480 (14827) | 14827..15168 | - | 342 | WP_002362432.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
NAG05_RS15485 (15168) | 15168..15398 | - | 231 | WP_002362431.1 | hypothetical protein | Antitoxin |
NAG05_RS15490 (15602) | 15602..16222 | + | 621 | WP_162500025.1 | recombinase family protein | - |
NAG05_RS15495 (16239) | 16239..16403 | + | 165 | WP_250652966.1 | hypothetical protein | - |
NAG05_RS15505 (17807) | 17807..18040 | + | 234 | WP_002394799.1 | hypothetical protein | - |
NAG05_RS15510 (18200) | 18200..18454 | - | 255 | WP_002394800.1 | hypothetical protein | - |
NAG05_RS15515 (18571) | 18571..19239 | - | 669 | WP_002403283.1 | CPBP family intramembrane metalloprotease | - |
NAG05_RS15520 (19275) | 19275..19592 | - | 318 | WP_002394802.1 | heavy metal-binding domain-containing protein | - |
NAG05_RS15525 (20087) | 20087..20197 | + | 111 | WP_002360667.1 | type I toxin-antitoxin system Fst family toxin | - |
- (20237) | 20237..20328 | - | 92 | NuclAT_0 | - | - |
- (20237) | 20237..20328 | - | 92 | NuclAT_0 | - | - |
- (20237) | 20237..20328 | - | 92 | NuclAT_0 | - | - |
- (20237) | 20237..20328 | - | 92 | NuclAT_0 | - | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | dfrG / aph(3')-III / erm(B) | - | 1..55867 | 55867 | |
- | flank | IS/Tn | - | - | 12631..13317 | 686 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13244.44 Da Isoelectric Point: 8.0113
>T246561 WP_002362432.1 NZ_CP098028:c15168-14827 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEHLPLKDMAKIDQIIEYIF
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEHLPLKDMAKIDQIIEYIF
Download Length: 342 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2Z2CGM4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R3KHK9 |