Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 30330..31467 Replicon plasmid pQZ076-1
Accession NZ_CP098026
Organism Enterococcus faecalis strain QZ076

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag NAG05_RS14865 Protein ID WP_032495456.1
Coordinates 30604..31467 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag NAG05_RS14860 Protein ID WP_000301765.1
Coordinates 30330..30602 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG05_RS14835 (NAG05_14835) 26644..26994 + 351 WP_010717225.1 hypothetical protein -
NAG05_RS14840 (NAG05_14840) 27511..28779 - 1269 Protein_28 PcfJ domain-containing protein -
NAG05_RS14845 (NAG05_14845) 28832..29512 - 681 WP_001067799.1 IS6-like element IS1216 family transposase -
NAG05_RS14850 (NAG05_14850) 29530..30006 + 477 Protein_30 ParA family protein -
NAG05_RS14855 (NAG05_14855) 30098..30313 + 216 WP_001835296.1 peptide-binding protein -
NAG05_RS14860 (NAG05_14860) 30330..30602 + 273 WP_000301765.1 antitoxin Antitoxin
NAG05_RS14865 (NAG05_14865) 30604..31467 + 864 WP_032495456.1 zeta toxin family protein Toxin
NAG05_RS14870 (NAG05_14870) 31909..32226 + 318 WP_002300567.1 hypothetical protein -
NAG05_RS14875 (NAG05_14875) 32245..32790 + 546 WP_250652962.1 molecular chaperone DnaJ -
NAG05_RS14880 (NAG05_14880) 32775..33083 + 309 WP_250652963.1 hypothetical protein -
NAG05_RS14885 (NAG05_14885) 33503..34552 + 1050 WP_250652957.1 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid cfr / fexA prgB/asc10 / EF0485 1..65961 65961
- inside IScluster/Tn cfr / fexA - 28832..44603 15771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32444.13 Da        Isoelectric Point: 6.9964

>T246559 WP_032495456.1 NZ_CP098026:30604-31467 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGIIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVASKEIQ
PTLERIEQKMILNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT246559 WP_000301765.1 NZ_CP098026:30330-30602 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References